α-Lipoic Acid, (S)-lipoic acid and (R)-lipoic acid？

May 25, 2022

α- Lipoic Acid is an antioxidant and an important cofactor of mitochondrial enzyme complex. It is often used as medicine and health care products.

There are very few lipoic acids in nature, which cannot be extracted and prepared. At present, all lipoic acids we can buy are synthetic, such as α-Lipoic Acid, (S)-lipoic acid and (R)-lipoic acid, etc

α- Lipoic acid is the general name of artificial lipoic acid. It is an impure mixture and contains two lipoic acid molecules with the same constituent elements and different three-dimensional structures: R-Lipoic acid and s-lipoic acid. Therefore, it is also called mixed rotary lipoic acid, CAS No.: 1077-28-7.

D-lipoic acid (R-Lipoic acid) and l-lipoic acid (s-lipoic acid) are two forms of Alpha Lipoic Acid, named after R and s respectively. They are chemical mirrors of each other. R isomer exists naturally in human body and can be absorbed more effectively than s isomer.

α- The current raw material production method of lipoic acid is synthesis method, in which the lipoic acid produced by the synthesis process with high cost performance is a racemic mixture, including half of R-Lipoic acid and half of s-lipoic acid. Physiological efficacy R-Lipoic acid is better, but the price of pure R-Lipoic acid is also more expensive (due to process reasons, the cost is higher).

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