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HomeNewsClinical application of lipoic acid

Clinical application of lipoic acid

2020-12-08
2.1 diabetes and its complications


2.1.1 diabetes

So far, according to the survey and statistics of diabetes branch of Chinese Medical Association, the number of diabetic patients in China has exceeded 92 million. "High prevalence rate and great harm" is the common characteristics of diabetes patients. Chronic diseases can cause multiple system damage, such as eye, kidney, nerve, heart, blood vessel and other chronic progressive diseases, which are the main causes of disability and death of patients. The mechanism of the short-term effect of octanoic acid on the treatment of diabetic cells was also demonstrated


And peripheral tissue insulin sensitivity, improve insulin resistance.


2.1.2 diabetic neuropathy

The clinical manifestations of diabetic neuropathy are numbness, pain, abnormal feeling, glove like or even muscle atrophy in the distal limb and trunk. Diabetic peripheral neuropathy may involve sensory nerve, motor nerve and autonomic nerve, resulting in motor and sensory disturbance. Therefore, lipoic acid, as an antioxidant, can improve the injured nerves by increasing the blood flow of neurotrophic vessels, improving nerve conduction velocity and restoring nerve energy pathway

Menstrual function and local microcirculation metabolism disorder. Zhang Chao and others from Jiamusi University selected 60 DPN patients with stable clinical metabolic indexes. They observed that lipoic acid combined with Mecobalamin in short-term treatment of DPN can significantly improve the clinical symptoms, nerve conduction velocity and lower extremity vascular disease.

2.2 neurology

Cerebral infarction includes cerebral thrombosis, cerebral embolism, lacunar ischemic stroke, multiple ischemic stroke and minor stroke. Free radical chain reaction is the main cause of cerebral ischemia injury. Therefore, early anti free radical therapy is very necessary. Lipoic acid mainly inhibits brain lipid peroxidation, protects brain nerve from free radical damage, and reduces the damage degree of cerebral infarction. This can prevent ischemic stroke or reduce the degree of brain damage in stroke patients. It is also said that lipoic acid can improve the curative effect of patients with acute cerebral infarction.

2.3 oncology

In the process of tumor formation, a large amount of oxygen free radicals are produced, which causes lipid peroxidation in vivo, and the concentration of antioxidants decreases, which promotes the malignant transformation of normal cells and accelerates the proliferation of tumor cells. At present, the commonly used anticancer drugs are targeting DNA, which will cause oxidative stress when they work, and normal tissues will also be damaged due to strong oxidative stress. Lipoic acid can effectively inhibit the deterioration of cancer patients by scavenging reactive oxygen species in normal cells and inhibiting the growth, proliferation and metastasis of tumor cells.

2.4 cardiovascular medicine

Atherosclerosis is one of the most common and important vascular diseases called arteriosclerosis. The main clinical manifestations were the symptoms of the involved organs. Lipoic acid mainly regulates blood lipid level, enhances antioxidant capacity and protects vascular endothelial function. Ji Wenqing of Qilu Hospital summarized the application of lipoic acid in atherosclerosis in detail, that is, α - lipoic acid and its reduced dihydrolipoic acid are highly effective antioxidants, which can remove free radicals and reactive oxygen species, chelate metal ions, regenerate glutathione, vitamin C and maintain life

Antioxidants such as Su-E can reduce oxidative stress, protect endothelial cells, and have good preventive and therapeutic effects on atherosclerosis and other cardiovascular diseases.

2.5 others

Because of its antioxidant mechanism, lipoic acid has been widely used in obstetrics and Gynecology, Stomatology, emergency and other departments, so it will not be detailed here.

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