High quality Atenolol CAS 29122-68-7

Chemical Raw Material Atenolol CAS 29122-68-7

purpose：

Atenolol is a selective β 1-adrenoceptor antagonist.

effect:
This drug is a long-acting and selective β 1-adrenoceptor blocker. Its cardiac selectivity is significantly stronger than metoprolol, but its inhibition on β 2 receptor of vascular and bronchial smooth muscle is weak. There was no endogenous sympathetic activity, no membrane stability and no inhibition of myocardial contractility. This product can reduce the blood pressure of patients with hypertension and reduce the increase of blood pressure caused by exercise. At the same time, reduce the heart rate (8% - 34%) and the product of heart rate and blood pressure (9% - 40%), reduce the severity and frequency of angina pectoris, and improve the oxygen consumption index of patients with acute myocardial infarction. Therefore, early application of the drug can reduce the size of myocardial infarction and prevent reinfarction, and long-term application can reduce the mortality of myocardial infarction or stroke.
After oral administration, the absorption rate was 50% - 60%, and the peak time of blood drug was 2-4 H. The bioavailability was about 60%, the plasma protein binding rate was about 46%, and the apparent distribution volume was 0.8l/kg. It is widely distributed in the body, a small amount of it enters the brain, can quickly pass through the placenta, and can accumulate in the milk, but the concentration of the drug in the baby's blood is very small. In adult patients with normal renal function, the elimination half time is about 5-7 hours, and the total clearance rate is about 6 L / h (100 ml / min). The half time of clearance in children was shorter (4,5 h). About 46% of the absorbed drugs were excreted from the urine in the original form. The clearance rate decreased in patients with abnormal renal function, which was mainly related to glomerular filtration rate.

Company profile：
Mingya Trading PTE.LTD.& Jinan Hongyuan Chemical &Shandong Lingjun Commerce & Trade Co. .Ltd. is a comprehensive trading company specializing in chemical solvents, chemical additives, Pharmaceutical Intermediates, APIs and other products. Since its establishment for 12 years, the company has won high recognition from customers at home and abroad by virtue of its rigorous, pragmatic and honest management style. It has established long-term close cooperative relations with hundreds of customers in more than 10 countries and regions
The company's advantages in the supply of Chemical Products, as well as intermediates of raw materials such as ethyl 6.8-dichlorooctanoate,DL-Lipoic acid, cetilistat, azilsartan, cilistat, etc. that products are of high quality and excellent service.

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Product Categories : Chemical Raw Material > Pesticide Intermediate